My research explores the mechanistic connection between gut dysbiosis (a compositional imbalance in the gut microbiota) and the onset of peripheral neuropathy. Specifically, I am examining how dysbiosis increases the translocation of lipopolysaccharide, a potent bacterial endotoxin, into systemic circulation. This triggers chronic low-grade inflammation, disrupts the integrity of the blood-nerve barrier, and may ultimately lead to peripheral nerve dysfunction. The objective is to confirm this molecular pathway, which may enable future development of microbiome-targeted countermeasures to mitigate neuropathic risk in vulnerable populations. Importantly, my research also aims to address a currently uncharacterized neuropathic health risk in long-duration mission astronauts, who are known to experience microgravity-induced shifts in gut microbial composition. Findings from this research may therefore inform both spaceflight medical planning and clinical care for at-risk neuropathic patients on Earth.
